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The authors suggest that the mice did not develop HSV1 encephalitis, the commonly known cause of mortality. Orally administered polyethylene glycol reversed the gastrointestinal “obstruction,” suggesting a mild functional type of slowed luminal transit, resembling constipation, rather than toxic megacolon, which cannot be reversed by an osmotic laxative without perforating the gut. Importantly, HSV1 infection affected the postjunctional mechanisms of smooth muscle relaxation like the sildenafil-response proteins, which may have been responsible for defective nitrergic neurotransmission and the delayed transit. The colon was only slightly dilated and benign appearing. In a severe form of mechanical and/or functional obstruction involving gross dilation of the colon and profound toxemia, the presentation is called “toxic megacolon.” The representative observations by Khoury-Hanold likely do not resemble toxic megacolon. The authors inferred that the mice died due to toxic megacolon. A small subset of mice succumbed after the first week of HSV1 infection. ( 1), genital infection of mice with herpes simplex virus 1 (HSV1) were reported to cause multiple pelvic organ involvement and obstruction.
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In an interesting investigation by Khoury-Hanold et al. 14ESIC Medical College, Sanathnagar, India.13All India Institute of Medical Sciences, New Delhi, India.12Baptist Hospital, Conway, AR, United States.11Neshoba County General Hospital, Philadelphia, MS, United States.10Beaumont Hospital, Grosse Pointe, MI, United States.9Northwest Medical Center, Bentonville, AR, United States.8Xenco Laboratories, Houston, TX, United States.7Woodland Memorial Hospital, Sacramento, CA, United States.6Berkshire Medical Center, Pittsfield, MA, United States.5Presbyterian Hospital, Denton, TX, United States.4Parkway Surgical and Cardiovascular Hospital, Fort Worth, TX, United States.3Wanderful Media/University of Southern California, Los Angeles, CA, United States.2Christus Trinity Mother Frances Hospital, Tyler, TX, United States.1GIM Foundation, Little Rock, AR, United States.Arun Chaudhury 1 *, Vijaya Sena Reddy Dendi 2, Mousumi Chaudhury 1, Astha Jain 3, Madhukar Reddy Kasarla 4, Kiran Panuganti 5, Gaurav Jain 6, Abhijit Ramanujam 7, Bhavin Rena 8, Sudheer Reddy Koyagura 9, Sumit Fogla 10, Sunil Kumar 11, Nawal Singh Shekhawat 12 and Srinivas Maddur 13,14